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MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children

Ma C Sánchez-Gómez1,2, K A García-Mejía1, M Pérez-Díaz Conti3

  • 1Laboratory of Developmental Biology Research and Experimental Teratogenicity, Children's Hospital of Mexico Federico Gomez (HIMFG), CP 06720, Mexico City, Mexico.

Pediatric Cardiology
|April 7, 2017
PubMed

Insights

Early diagnosis of congenital heart disease (CHD) is crucial. Specific microRNAs (miRNAs) in cardiac tissue and plasma show promise as biomarkers for diagnosing cardiac hypertrophy (CH) in infants with CHD.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Pediatrics

Background:

  • Complex congenital heart disease (CHD) causes ventricular pressure overload, leading to cardiac hypertrophy (CH), myocardial dysfunction, and increased mortality risk.
  • Early diagnosis and surgical intervention in infants with CHD are critical for survival.

Purpose of the Study:

  • To investigate the expression of 11 adult CH-specific microRNAs (miRNAs) in pediatric cardiac tissue and plasma.
  • To identify potential miRNA biomarkers for early diagnosis of CH in infants with CHD.

Main Methods:

  • Analysis of miRNA expression in cardiac tissue and plasma from children with CH secondary to CHD.
  • Comparison of miRNA profiles with those from healthy children.

Main Results:

  • A specific miRNA expression profile (miRNAs 1, 18b, 21, 23b, 133a, 195, and 208b) was identified in the cardiac tissue of children with CHD.
  • miRNAs 21, 23a, 23b, and 24 were identified as potential specific biomarkers for diagnosing CH in infants with CHD.

Conclusions:

  • Cardiac hypertrophy secondary to CHD in children exhibits distinct mechanisms compared to adult hypertrophy.
  • Identified miRNAs hold potential as biomarkers for the early detection of CH in pediatric CHD patients, offering new research avenues.

Keywords:
Cardiac hypertrophyChildrenComplex congenital heartMicroRNAs

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