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Related Experiment Videos

Lymphoma Classification in Goats.

Patti K Kiser1, Christiane V Löhr1

  • 11 Department of Biomedical Sciences, Oregon Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA.

Veterinary Pathology
|April 7, 2017
PubMed
Summary
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This study systematically characterized caprine lymphoma, finding T-cell lymphoma (TCL) is predominant in goats, unlike dogs and horses. Lymphomas frequently involved the mediastinum, suggesting thymic origins.

Area of Science:

  • Veterinary Pathology
  • Oncology
  • Immunohistochemistry

Background:

  • Individual caprine lymphoma cases are documented, but systematic characterization in a larger cohort is lacking.
  • Understanding caprine lymphoma subtypes is crucial for accurate diagnosis and treatment strategies.

Purpose of the Study:

  • To subtype caprine lymphoma using the World Health Organization classification system.
  • To determine the immunophenotype, topographic, and subgross distribution of caprine lymphomas.
  • To compare caprine lymphoma characteristics with those in other domestic animals.

Main Methods:

  • Fifteen caprine lymphoma cases (6 biopsy, 9 postmortem) were analyzed.
  • Immunohistochemistry was used to determine T-cell lymphoma (TCL) and B-cell lymphoma (BCL) phenotypes.
Keywords:
CD3CD79αgoatsimmunohistochemistrylymphomalymphosarcomamulticentricthymus

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  • Nuclear size was measured and adjusted for species-specific differences.

    • Main Results:

    • T-cell lymphoma (TCL) accounted for 73% (11/15) of cases, while B-cell lymphoma (BCL) comprised 27% (4/15).
    • Multicentric distribution was most common; TCL frequently involved the thoracic cavity/neck, suggesting thymic origin.
    • TCL subtypes included lymphoblastic, large granular lymphocyte, diffuse small lymphocytic, and peripheral/mature T-cell lymphomas.
    • BCL subtypes included diffuse large B-cell lymphoma and B-cell lymphocytic lymphoma intermediate type.

    Conclusions:

    • Caprine lymphomas are predominantly T-cell lymphomas (TCL), differing from dogs and horses.
    • The frequent involvement of the mediastinum in TCL suggests a thymic origin or homing.
    • This systematic characterization provides a foundation for understanding and managing caprine lymphoma.