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(Diacetoxy)iodobenzene-Mediated Oxidative C-H Amination of Imidazopyridines at Ambient Temperature
Susmita Mondal1, Sadhanendu Samanta1, Sourav Jana1
1Department of Chemistry, Visva-Bharati (A Central University) , Santiniketan 731235, India.
The Journal of Organic Chemistry
|April 7, 2017
Abstract:
(Diacetoxy)iodobenzene (PIDA)-mediated direct oxidative C-H amination for the synthesis of 3-amino substituted imidazopyridines has been achieved under metal-free conditions at room temperature in short reaction times. This methodology is also applicable for the regioselective amination of indolizines. Experimental results suggest that the reaction likely proceeds through a radical pathway.