Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emerging Therapies for Sensorineural Hearing Loss.

Matthew Gordon Crowson1, Ronna Hertzano, Debara L Tucci

  • 1*Division of Head & Neck Surgery and Communication Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina †Department of Otorhinolaryngology-Head & Neck Surgery, Anatomy and Neurobiology and Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland.

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology
|April 7, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autologous Mastoid Cortex Bone Graft for Multilayer Repair of Lateral Skull Base Defects.

The Laryngoscope·2026
Same author

Engineering of functional auditory neurons from human induced pluripotent stem cells.

Military Medical Research·2026
Same author

Epithelial-Mesenchymal Wnt Crosstalk Directs Planar Cell Polarity in the Developing Cochlea.

bioRxiv : the preprint server for biology·2026
Same author

NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development.

Nature neuroscience·2026
Same author

EPHRIN-A1 and -A2 act as positive growth factors for developing spiral ganglion radial bundles.

Developmental biology·2025
Same author

Barriers to Research for Academic Otologists/Neurotologists in the United States.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2025

Current clinical trials for sensorineural hearing loss focus on reducing oxidative stress and cell death. Novel cell replacement therapies show promise but face challenges in human translation.

Area of Science:

  • Otolaryngology
  • Regenerative Medicine
  • Pharmacology

Background:

  • Sensorineural hearing loss (SNHL) is a significant health concern with limited treatment options.
  • Existing therapies primarily focus on managing symptoms rather than addressing underlying causes.
  • Advances in understanding inner ear biology have opened new avenues for therapeutic development.

Purpose of the Study:

  • To critically review and evaluate proposed mechanisms and documented results of therapeutics in active clinical trials for SNHL.
  • To identify common themes and novel approaches in current SNHL drug development.
  • To assess the potential and challenges of translating preclinical findings to clinical efficacy.

Main Methods:

  • Systematic review of the US National Institutes of Health (NIH) Clinical Trials registry.

Related Experiment Videos

  • Literature search of MEDLINE/PubMed for supporting publications.
  • Critical appraisal of proof-of-concept, therapeutic mechanisms, and clinical outcomes for identified therapies.

    • Main Results:

    • Twenty-two active clinical trials for SNHL were identified, focusing on six therapeutic molecules.
    • Four molecules target oxidative stress pathways implicated in inner ear cell death.
    • One therapy modulates the cell death cascade, and another explores cell replacement via transcription factors for hair cell regeneration.

    Conclusions:

    • Current SNHL therapeutics in clinical trials predominantly target cell death pathways and oxidative stress.
    • A novel virus-delivered cell replacement therapy represents a first-in-kind approach.
    • Significant challenges remain in translating preclinical results to human efficacy, including species differences and understanding complex biological processes like immune response and synaptic loss.