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In-hospital outcomes of premature infants with severe bronchopulmonary dysplasia

W Jackson1, C P Hornik2,3, J A Messina2

  • 1Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Journal of Perinatology : Official Journal of the California Perinatal Association
|April 7, 2017
PubMed

Insights

Most premature infants with severe bronchopulmonary dysplasia (BPD) survive hospitalization. The majority of these infants with severe BPD are discharged by 44 weeks postmenstrual age.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Perinatology

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting premature infants.
  • Severe BPD presents significant challenges in neonatal intensive care units (NICUs).

Purpose of the Study:

  • To characterize the in-hospital outcomes of premature infants diagnosed with severe bronchopulmonary dysplasia (BPD).

Main Methods:

  • Retrospective cohort study.
  • Data collected from 348 NICUs within the Pediatrix Medical Group from 1997 to 2015.
  • Included premature infants diagnosed with severe BPD.

Main Results:

  • 10,752 infants with severe BPD were identified.
  • Mortality rate before discharge was 5% (549 infants).
  • Infants who died were more likely to be male, small for gestational age, and have comorbidities like surgical necrotizing enterocolitis, sepsis, and pulmonary hypertension.

Conclusions:

  • Most infants with severe BPD are discharged by 44 weeks postmenstrual age (70%) or 48 weeks (86%).
  • Findings can help inform discussions with families about the expected hospital course.
  • Understanding outcomes is crucial for managing severe BPD in premature infants.
Abstract

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