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Radioiododemercuration: a simple synthesis of 5-[123/125/127I]iodo-2'-deoxyuridine
J Baranowska-Kortylewicz1, B M Kinsey, W W Layne
1Department of Radiology (Nuclear Medicine), Harvard Medical School, Boston, MA 02115.
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
|January 1, 1988
Abstract:
Through the use of iododemercuration, 5-[123/125I]iodo-2'-deoxyuridine was synthesized rapidly and with high radiochemical purity from 5-chloromercuri-2'-deoxyuridine. The synthesis of radioiodinated 2'-deoxyuridine was achieved in one step in the presence of Iodogen in 50% yield after isolation by reverse phase high performance column chromatography. The radiochemical purity was greater than 99%. The ease and the absence of any starting material, suggests that radiohalodemercuration may be the method of choice for this and structurally similar compounds.