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Related Experiment Videos

Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties.

Weinan Sun1, Kasper B Hansen2, Craig E Jahr1

  • 1Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.

Neuron
|April 7, 2017
PubMed
Summary

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Triheteromeric NMDA receptors (NMDARs) exhibit allosteric interactions between GluN2 subunits, primarily driven by GluN2A. This results in unique functional properties not seen in simpler NMDARs, impacting synaptic signaling.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Synaptic Plasticity

Background:

  • During central nervous system development, NMDA receptor (NMDAR) subunit composition shifts, accelerating synaptic currents.
  • This shift involves increased GluN2A and triheteromeric GluN1/2A/2B NMDARs, and decreased diheteromeric GluN1/2B NMDARs.

Purpose of the Study:

  • To investigate allosteric interactions between GluN2 subunits in triheteromeric GluN1/2A/2B NMDARs.
  • To understand how these interactions influence NMDAR function and kinetics.

Main Methods:

  • Electrophysiological recordings of NMDAR currents.
  • Analysis of receptor kinetics and subunit interactions.

Main Results:

  • Allosteric interactions between GluN2 subunits were identified in triheteromeric GluN1/2A/2B NMDARs.
Keywords:
GluN2 subunitTriheteromeric NMDA receptorsallosteric interactionamino-terminal domaincrosslinkingexcitatory synaptic transmissionglutamateopen probabilityreceptor deactivation

Related Experiment Videos

  • GluN2A subunit dominance in these interactions leads to functional properties distinct from diheteromeric receptors.
  • Triheteromeric NMDARs combine GluN2B-like signaling with GluN2A-like kinetics.

    • Conclusions:

    • Triheteromeric GluN1/2A/2B NMDARs exhibit complex signaling due to inter-subunit allosterism.
    • These findings reveal novel functional properties of NMDARs and underscore the impact of subunit diversity on synaptic transmission.