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Related Experiment Videos

Polymyxin B-Induced Diffuse Cutaneous Hyperpigmentation.

Sandeep Lahiry1, Shouvik Choudhury2, Ayan Mukherjee2

  • 1Post Graduate Trainee, Department of Pharmacology, Institute of Post Graduate Medical Education and Research , Kolkata, West Bengal, India.

Journal of Clinical and Diagnostic Research : JCDR
|April 8, 2017
PubMed
Summary
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Polymyxin B, an antibiotic for resistant Gram-negative infections, may cause skin hyperpigmentation. This rare side effect was observed in a patient treated for Multi-Drug Resistant Klebsiella pneumoniae.

Area of Science:

  • Pharmacology
  • Dermatology
  • Infectious Diseases

Background:

  • Polymyxin B is a critical antibiotic for treating infections caused by multidrug-resistant Gram-negative bacteria, including Pseudomonas aeruginosa and Acinetobacter baumannii.
  • Its use is limited by potential toxicities, such as neurotoxicity and nephrotoxicity.

Observation:

  • A rare case of cutaneous hyperpigmentation is presented in a 65-year-old male of Indian origin.
  • The patient was being treated with intravenous antibiotics for Multi-Drug Resistant Klebsiella pneumoniae infection.

Findings:

  • The skin hyperpigmentation manifested after four days of initiating Polymyxin B therapy.
  • Other potential causes for the hyperpigmentation, including concomitant medications, infections, and immunological disorders, were systematically excluded.
Keywords:
Drug reactionKlebsiellaMultidrug resistant

Related Experiment Videos

  • Causality assessment suggests a possible association between Polymyxin B therapy and the observed cutaneous hyperpigmentation.

    • Implications:

    • This case highlights a rare but notable adverse effect of Polymyxin B therapy.
    • Further research is warranted to elucidate the underlying mechanisms of Polymyxin B-induced hyperpigmentation.
    • Clinicians should be aware of this potential side effect when prescribing Polymyxin B, especially for extended durations.