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A new phthalide from the endophytic fungus Xylaria sp. GDG-102
Na Zheng1, Feihua Yao1, Xuefeng Liang1
1a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University , Guilin , P.R. China.
Abstract:
A new phthalide derivative, xylarphthalide A (1), along with two known compounds (-)-5-carboxylmellein (2) and (-)-5-methylmellein (3), were isolated from the endophytic fungus Xylaria sp. GDG-102 cultured from the Chinese medicinal plant Sophora tonkinensis. Their structures were identified by MS and NMR experiments, and the absolute configuration of 1 was further confirmed by single-crystal X-ray diffraction analysis. Compound 1-3 showed antibacterial activities against Bacillus megaterium, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Shigella dysenteriae with MIC values of 12.5-25 μg/mL.