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Related Experiment Videos

Diffusion Tensor Imaging Parameter Obtained during Acute Blunt Cervical Spinal Cord Injury in Predicting Long-Term

Kathirkamanathan Shanmuganathan1, Jaichen Zhuo1, Hegang H Chen2

  • 11 Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine , Baltimore, Maryland.

Journal of Neurotrauma
|April 8, 2017
PubMed
Summary

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Diffusion tensor imaging (DTI) shows promise for predicting recovery after cervical spinal cord injury (CSCI). Axial diffusivity (AD) measured early after injury strongly correlates with long-term motor and functional outcomes.

Area of Science:

  • Neuroimaging
  • Spinal Cord Injury Research
  • Biomarker Discovery

Background:

  • Reliable neuroimaging biomarkers for predicting long-term outcomes after spinal cord injury are lacking.
  • Diffusion tensor imaging (DTI) offers potential for assessing white matter integrity.

Purpose of the Study:

  • To evaluate DTI parameters for predicting long-term neurological and functional outcomes in patients with cervical spinal cord injury (CSCI).

Main Methods:

  • Prospective longitudinal study of 30 CSCI patients and 15 controls, with MRI within 24 hours of injury.
  • Measured DTI parameters, including axial diffusivity (AD), and correlated them with ISNCSCI motor and SCIM III scores at one year.
  • Used stepwise regression analysis, incorporating DTI values, age, sex, and hemorrhagic contusion (HC).
Keywords:
cervical spinediffusion tensor imagingmagnetic resonancetraumatic spinal cord injury

Related Experiment Videos

Main Results:

  • Axial diffusivity (AD) showed the strongest correlation with one-year motor (r²=0.76) and SCIM III scores (r²=0.77).
  • A regression model including AD and presence of HC best predicted one-year ISNCSCI scores (r²=0.93).
  • AD appears more specific to axonal injury, suggesting axonal damage is key to recovery.

Conclusions:

  • DTI measurement, particularly AD, at the time of CSCI is a potential neuroimaging biomarker for predicting long-term neurological and functional recovery.
  • Axonal injury, as indicated by AD, is a critical factor influencing patient outcomes after blunt CSCI.