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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Identification and Characterization of Canine Ligament Progenitor Cells and Their Extracellular Matrix Niche.

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A comparison of the stem cell characteristics of murine tenocytes and tendon-derived stem cells.

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Related Experiment Video

Updated: Jun 23, 2026

Isolating Stem Cells from Soft Musculoskeletal Tissues
07:49

Isolating Stem Cells from Soft Musculoskeletal Tissues

Published on: July 5, 2010

Ligament-Derived Stem Cells: Identification, Characterisation, and Therapeutic Application.

Katie Joanna Lee1, Peter David Clegg2, Eithne Josephine Comerford3

  • 1Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UK.

Stem Cells International
|April 8, 2017
PubMed
Summary
This summary is machine-generated.

Stem cell therapy offers a promising new treatment for ligament injuries. This review explores ligament-derived stem cells (LDSCs) beyond the periodontal ligament, focusing on their characteristics and therapeutic potential.

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Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
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Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

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Last Updated: Jun 23, 2026

Isolating Stem Cells from Soft Musculoskeletal Tissues
07:49

Isolating Stem Cells from Soft Musculoskeletal Tissues

Published on: July 5, 2010

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
11:31

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

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Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
09:31

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

Published on: March 30, 2018

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Orthopedics

Background:

  • Ligaments have limited healing capacity, necessitating novel therapeutic approaches.
  • Current treatments for ligament injury and degeneration are often ineffective.
  • Stem cell therapy presents a potential solution for improving ligament repair.

Purpose of the Study:

  • To review current knowledge on nondental ligament-derived stem cells (LDSCs).
  • To summarize the in vitro characteristics of LDSCs from various ligament types.
  • To explore the therapeutic potential of LDSCs and their niche modulation.

Main Methods:

  • Literature review of studies on nondental LDSCs.
  • Analysis of in vitro characteristics and functional properties of LDSCs.
  • Discussion of the stem cell niche's influence on LDSC phenotype and viability.

Main Results:

  • LDSC populations have been identified in various ligament types, with a growing research focus beyond periodontal ligament.
  • In vitro studies reveal specific characteristics of LDSCs relevant to tissue regeneration.
  • The stem cell niche significantly influences LDSC behavior and therapeutic efficacy.

Conclusions:

  • Nondental LDSCs represent a promising source for regenerative therapies in ligament repair.
  • Understanding and modulating the LDSC niche can enhance their therapeutic potential.
  • Further research into LDSC niche interactions is crucial for clinical translation.