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Pathogenesis of Warthin's tumors
Yevhen V Kuzenko1, Anatoly M Romanuk1, Olena Olegivna Dyachenko1
1Department of Pathology, Medical Institute of Sumy State University , Sumy, Ukraine.
Interventional Medicine & Applied Science
|April 8, 2017
Summary
Warthin's tumor pathogenesis involves an inflammatory etiology, with epithelial components triggering the tumor process. Immunohistochemistry revealed specific immune cell markers within the tumor's stroma and follicles.
Area of Science:
- Oncology
- Pathology
- Immunology
Background:
- Warthin's tumor, also known as papillary cystadenoma lymphomatosum, is a benign salivary gland tumor.
- It is characterized by abundant lymphocytes and lymph node-like stroma.
- Named after pathologist Aldred Scott Warthin, it was first described in 1929.
Purpose of the Study:
- To analyze the pathogenesis of Warthin's tumor.
- To investigate the expression of various markers in Warthin's tumor tissue.
- To understand the role of immune cells and epithelial components in tumor development.
Main Methods:
- Studied 15 patients diagnosed with Warthin's tumor.
- Utilized Hematoxylin and eosin staining for histopathological evaluation.
- Performed immunohistochemistry for markers including MGMT, CD3, HSP90AA1, MMP-1, Bcl-2, CD79A, IgG, Ki-67, p53, IgM, OPN, S100, myeloperoxidase, and VEGF.
Main Results:
- Immunohistochemistry showed immune cells positive for MGMT, Ki-67, Bcl-2, and p53 within tumor follicles.
- CD3-positive immune cells were found in the stroma but not in epithelial layers.
- CD79A-positive B cells formed germinal centers within the immune cells, indicating follicular structures.
Conclusions:
- Histopathological analysis showed a balanced distribution of epithelial and stromal components.
- The epithelial component is identified as the trigger for the Warthin's tumor development.
- The study concludes that Warthin's tumor arises from an inflammatory etiology.