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Structure of Cadherins

Structure of Cadherins

The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This diversity of cadherins...

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Related Experiment Video

Updated: Jul 14, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Published on: March 17, 2014

Protective role of Cadherin 13 in interneuron development.

Abigail C Killen¹, Melissa Barber¹, Joshua J W Paulin²

¹Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.

Brain Structure & Function

|April 8, 2017

Summary

Cadherin-13 (Cdh13) plays a protective role in cortical neuron development. Loss of Cdh13 in mice leads to reduced neuron numbers and increased cell death during late-stage cortical development.

Keywords:

Apoptosis Cadherin Cell migration Interneurons

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Last Updated: Jul 14, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

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Published on: March 17, 2014

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

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Published on: October 17, 2014

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

Area of Science:

Neuroscience
Developmental Biology
Molecular Biology

Background:

Cortical interneurons originate in ganglionic eminences and migrate through the telencephalon.
Two distinct streams of migrating interneurons are observed in the developing cortex.
Cadherin-13 (Cdh13) was identified as a differentially expressed gene in these migratory streams.

Purpose of the Study:

To identify genes involved in cortical interneuron migration and specification.
To investigate the role of Cadherin-13 (Cdh13) in cortical development.

Main Methods:

Microarray analysis to identify differentially expressed genes.
Expression analysis of Cdh13 in developing mouse cortex.
Phenotypic analysis of Cdh13 knockout mice at different developmental stages (E15.5 and E18.5).
In vitro studies using dissociated cell cultures with overexpression and siRNA techniques.

Main Results:

Cdh13 expression is detected in the preplate and later in cortical interneurons and pyramidal cells.
Cdh13 knockout mice showed a significant reduction in interneurons and late-born pyramidal neurons at E18.5, but not E15.5.
An increase in apoptotic cells was observed in the cortex of Cdh13 knockout mice at E18.5.
In vitro experiments confirmed the protective role of Cdh13.

Conclusions:

Cadherin-13 (Cdh13) has a novel protective function in cortical neuron development.
Cdh13 is crucial for the survival of interneurons and pyramidal neurons during late cortical development.
Cdh13 may be important for maintaining neuronal homeostasis and preventing apoptosis in the developing cortex.