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Related Experiment Videos

[Pediatric reference intervals : retrospective study on thyroid hormone levels].

A Ladang1, L Vranken1, F Luyckx2

  • 1Département de Chimie clinique, Biologie clinique, CHU de Liège, Site Sart Tilman, Liège, Belgique.

Revue Medicale De Liege
|April 8, 2017
PubMed
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This study establishes new pediatric reference ranges for thyroid hormones (TSH, FT3, FT4) using the Cobas C6000 analyzer. These ranges are crucial for accurate thyroid disorder diagnosis in children aged 0-18.

Area of Science:

  • Endocrinology
  • Clinical Chemistry
  • Pediatric Diagnostics

Context:

  • Establishing accurate reference ranges for thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) is vital for pediatric diagnostics.
  • Previous studies have noted age and sex influences on thyroid hormone levels, necessitating specific pediatric ranges.
  • The Cobas C6000 analyzer is widely used, making analyzer-specific reference ranges essential for consistent clinical application.

Purpose:

  • To define new, age-specific pediatric reference ranges for TSH, FT3, and FT4 specifically for the Cobas C6000 analyzer.
  • To account for significant thyroid hormone fluctuations in infants and stabilization around age three.
  • To compare the derived pediatric reference ranges with those from a large-scale Canadian study (CALIPER initiative).
Keywords:
PediatricThyroid hormone levelReference range

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Summary:

  • This study determined new pediatric reference ranges for TSH, FT3, and FT4 in outpatients aged 0 to 18 years using the Cobas C6000 analyzer.
  • Thyroid hormone levels were analyzed considering dramatic changes in the first year of life and stabilization around age three.
  • The results were benchmarked against data from the CALIPER initiative, a large Canadian prospective study.

Impact:

  • Provides essential, updated reference ranges for TSH, FT3, and FT4 tailored for the Cobas C6000 in pediatric populations.
  • Aids clinicians in the accurate diagnosis and monitoring of thyroid conditions in children and adolescents.
  • Facilitates improved standardization of thyroid function testing across different laboratories and geographic regions.