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Related Experiment Videos

[Bilateral angle-closure glaucoma induced by topiramate].

O Beaudry1, V Goncette2, N Collignon1

  • 1Service d'Ophtalmologie, CHR Citadelle, Liège, Belgique.

Revue Medicale De Liege
|April 8, 2017
PubMed
Summary

Topiramate, a migraine prophylactic drug, can rarely cause bilateral angle-closure glaucoma. Prompt ophthalmologic recognition and management are crucial to prevent irreversible vision loss from this idiosyncratic reaction.

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Area of Science:

  • Ophthalmology
  • Neurology
  • Pharmacology

Background:

  • Topiramate (TPM) is a widely prescribed medication for migraine prophylaxis.
  • Migraine prophylaxis aims to reduce migraine frequency and severity.
  • Idiosyncratic drug reactions can manifest with diverse and unpredictable side effects.

Observation:

  • Topiramate has been associated with bilateral angle-closure glaucoma.
  • This ocular side effect is considered a rare, idiosyncratic response.
  • Angle-closure glaucoma can occur due to specific physiological reactions to the drug.

Findings:

  • The occurrence of glaucoma is linked to an idiosyncratic response to Topiramate.
  • Early recognition of this adverse drug event is critical for patient outcomes.
Keywords:
Bilateral angle closure glaucomaMigraineTopiramate

Related Experiment Videos

  • Timely intervention by an ophthalmologist is essential for managing the condition.

    • Implications:

    • Untreated angle-closure glaucoma secondary to Topiramate can result in permanent vision impairment.
    • Ophthalmologists must be vigilant for this rare side effect in patients using Topiramate.
    • Awareness among healthcare providers can mitigate the risk of vision loss associated with Topiramate therapy.