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[Skin carcinogenesis in renal transplant recipients]
G E Piérard1,2, C Piérard-Franchimont3, P Delvenne3
1Département des Sciences cliniques, Université de Liège et Service de Dermatopathologie, CHU de Liège, Site du Sart Tilman, Liège, Belgique.
Abstract:
Organ transplants are bound to the induction and upkeep of immunosuppression. The immunomodulatory regimen modalities have changed over time with an improvement of the overage graft survival. The effects are also present on the skin and its cancerogenesis which is particularly activated for the squamous cell carcinoma. A review of the recent medical literature reveals the importance of searching squamous cell carcinomas, actinic keratoses, seborrheic keratoses and keratocanthomas before and after organ transplants. The severity of the carcinomas is due to their multiplicity and to the progressive occurrence of more aggressive lesions. Prevention relies on a strict adherence to sun protection after transplantation and on refined immunosuppressive strategies.