Deregulation of the non-coding genome in leukemia
Related Experiment Video
Updated: Jun 27, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
Published on: June 16, 2017
Susanna Teppo1, Merja Heinäniemi2, Olli Lohi1
1a Tampere Center for Child Health Research, Faculty of Medicine and Life Sciences , University of Tampere and Tampere University Hospital , Tampere , Finland.
Abstract:
Methodological advances that allow deeper characterization of non-coding elements in the genome have started to reveal the full spectrum of deregulation in cancer. We generated an inducible cell model to track transcriptional changes after induction of a well-known leukemia-inducing fusion gene, ETV6-RUNX1. Our data revealed widespread transcriptional alterations outside coding elements in the genome. This adds to the growing list of various alterations in the non-coding genome in cancer and pinpoints their role in diseased cellular state.
More Related Videos
Related Concept Videos
Organization of Genes
Epigenetic Regulation
lncRNA - Long Non-coding RNAs
Lineage Commitment
lncRNA - Long Non-coding RNAs
Epigenetic Regulation
X-chromosome...

