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Identification of human IgG1 variant with enhanced FcRn binding and without increased binding to rheumatoid factor

Atsuhiko Maeda1, Yuki Iwayanagi2, Kenta Haraya3

  • 1a Chugai Pharmaceutical Co. Ltd., Pharmaceutical Technology Division, Ukima Research Labs. , Ukima, Kita-ku , Tokyo , Japan.

Mabs
|April 8, 2017
PubMed

Keywords:
Antibody therapeuticsCH2-CH3 interfaceFc engineeringFcRnRFpharmacokineticspre-existing ADArheumatoid factorsweeping antibodyimmunoglobulin G1pharmacokineticsautoimmune diseaseprotein engineering

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