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Synchrotron FTIR mapping of mineralization in a microfluidic device
Shunbo Li1, Johannes Ihli, William J Marchant
1School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK. F.Meldrum@leeds.ac.uk.
Lab on a Chip
|April 8, 2017
Summary
This study introduces a novel microfluidic device for label-free analysis of aqueous solutions using Fourier transform infrared (FTIR) micro-spectroscopy. The device enables real-time monitoring of crystallization processes, overcoming signal saturation issues common in aqueous samples.
Area of Science:
- Analytical Chemistry
- Materials Science
- Geochemistry
Background:
- Fourier transform infrared micro-spectroscopy (FTIR) is valuable for label-free specimen analysis.
- Analysis of aqueous solutions via FTIR is challenging due to strong water absorption, causing signal saturation.
Purpose of the Study:
- To develop a novel microfluidic device to overcome signal saturation in FTIR analysis of aqueous solutions.
- To enable real-time, in situ monitoring of crystallization processes in aqueous environments.
Main Methods:
- Fabrication of microfluidic devices with 3 μm channel depths using calcium fluoride (CaF2).
- Utilized photolithography and hot embossing bonding for device construction.
- Employed synchrotron FTIR micro-spectroscopy for high-resolution analysis.
Main Results:
- Demonstrated the device's utility by tracking calcium sulfate and calcium carbonate precipitation pathways.
- Acquired time-resolved, hyperspectral maps of mineral particles formed within the sample cell.
- Observed particle interactions and evolution during crystallization.
Conclusions:
- The novel CaF2 microfluidic device effectively overcomes signal saturation in aqueous FTIR analysis.
- This in situ, real-time detection system provides powerful insights into crystal formation and evolution.
- The method offers new understanding of crystallization processes in confined volumes.