Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A clinical update on inflammasomopathies.

Hafize Emine Sönmez1, Seza Özen1

  • 1Department of Pediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey.

International Immunology
|April 8, 2017
PubMed
Summary

Inflammasomes are key to innate immunity. Defects in these immune sensors cause inflammasomopathies, a group of autoinflammatory diseases. This review highlights recent advances and international research in diagnosing and treating these conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multicentre study for clinical phenotype prediction in juvenile dermatomyositis: categorical principal component analysis-based hierarchical clustering.

Reumatologia·2026
Same author

Factors predicting the severity of gastrointestinal involvement in children with IgA vasculitis? A Turkish multicenter cohort study.

European journal of pediatrics·2026
Same author

Development of a mobile health application to support the management of paediatric FMF.

Rheumatology (Oxford, England)·2026
Same author

How Well Do the New EULAR/ACR Classification Criteria Capture Pediatric Chronic Nonbacterial Osteomyelitis? A Multicenter Pediatric Cohort Study.

Journal of pediatric orthopedics·2026
Same author

Juvenile vs. Adult-Onset Spondyloarthritis: Uncovering Similarities and Differences.

Archives of rheumatology·2026
Same author

Decoding joint complaints in children: a diagnostic approach to rheumatic and non-rheumatic disorders.

The Turkish journal of pediatrics·2026

Area of Science:

  • Immunology
  • Genetics
  • Rheumatology

Background:

  • Inflammasomes are crucial components of the innate immune system.
  • Hereditary defects in inflammasomes lead to autoinflammatory syndromes known as inflammasomopathies.
  • These conditions encompass both common and rare diseases.

Purpose of the Study:

  • To review recent clinical advances in inflammasomopathies.
  • To emphasize international collaborative efforts in the field.
  • To provide updated recommendations for diagnosis and treatment.

Main Methods:

  • Review of recent clinical advances and international collaborative work.
  • Presentation of updated recommendations for familial Mediterranean fever, cryopyrin-associated periodic syndromes, and hyper-IgD syndrome/mevalonate kinase deficiency.
Keywords:
autoinflammatory diseaseschildinflammasome

Related Experiment Videos

  • Brief discussion of rare inflammasomopathies based on clinical features.

    • Main Results:

    • Summarizes diagnostic tests, treatment alternatives, and follow-up recommendations for common inflammasomopathies.
    • Discusses clinical features of rare inflammasomopathies including NLRC4-related MAS, NLRP12-related periodic fever, and NLRP1-associated autoinflammation.
    • Highlights progress in understanding and managing these complex genetic disorders.

    Conclusions:

    • Recent advances have improved the diagnosis and management of inflammasomopathies.
    • International collaboration is vital for addressing these rare autoinflammatory diseases.
    • Updated guidelines offer a framework for optimal patient care.