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Amlodipine: The double edged sword
Fatma Rabah1, Mohamed El-Naggari1, Dana Al-Nabhani1
1Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman.
Aim:
Amlodipine, a calcium channel blocker became one of the most popular antihypertensive medications used in the paediatric population. This is mainly due to its long half-life making it easy to use as a single daily dose. Amlodipine is associated with common side effects like flushing, headache and dizziness. The incidence of amlodipine-related oedema was noted to be lower in the paediatric population compared to adults. We emphasise the importance of monitoring the development of oedema in patients treated with amlodipine.
Methods:
Hereby, we report four paediatric cases with amlodipine-related generalised oedema.
Conclusion:
Resolution of the oedema with stoppage of amlodipine confirms its culprit as a cause of the oedema. To our knowledge, this is the largest case series of amlodipine-related generalised oedema in the paediatric population.
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