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Related Experiment Videos

Summary Points and Consensus Recommendations From the International Protein Summit.

Ryan T Hurt1,2, Stephen A McClave2, Robert G Martindale3

  • 11 Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition
|April 8, 2017
PubMed

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Summary

High-dose protein (1.2-2.5 g/kg/d) in intensive care units (ICUs) may optimize nutrition and preserve muscle mass. Prioritizing protein over calories in the first week is crucial for critically ill patients.

Area of Science:

  • Clinical Nutrition
  • Protein Metabolism
  • Critical Care Medicine

Background:

  • Experts convened at the 2016 International Protein Summit to discuss high-dose protein administration in critically ill patients.
  • Current evidence suggests a protein intake of 1.2-2.5 g/kg/d may be necessary in the intensive care unit (ICU) to optimize nutrition therapy and reduce mortality.
  • High protein doses may stimulate protein synthesis and preserve muscle mass, despite not fully blunting catabolism.

Purpose of the Study:

  • To determine the impact of high-dose protein administration on clinical outcomes in critically ill patients.
  • To identify barriers to effective protein delivery in the ICU.
  • To provide evidence-based recommendations for clinical practice and future research.

Main Methods:

Keywords:
amino acidsenteral nutritionlean body massparenteral nutritionprotein

Related Experiment Videos

  • Review and assessment of current literature on protein metabolism and clinical nutrition in critical care.
  • Synthesis of expert opinions and findings from the 2016 International Protein Summit.
  • Development of clinical practice recommendations and research directions.

    • Main Results:

    • High-dose protein (1.2-2.5 g/kg/d) may be required in ICUs to optimize nutrition and preserve muscle mass.
    • Protein quality, including amino acid profile and digestibility, influences nutrient sensing pathways.
    • Prioritizing protein goals over energy goals in the first week of ICU admission is recommended.
    • High-protein, hypocaloric feeding may be an effective strategy for high-nutrition-risk patients.

    Conclusions:

    • High-protein nutrition strategies are essential for optimizing outcomes in critically ill patients.
    • Further research is needed to refine protein dosing and delivery in critical care.
    • Healthcare professionals should consider prioritizing protein intake to improve patient recovery and reduce mortality.