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Immature platelet fraction and the extent of coronary artery disease: A single centre study
Monica Verdoia1, Matteo Nardin2, Roberta Rolla3
1Department of Cardiology, Ospedale "Maggiore della Carità", Università del Piemonte Orientale, Novara, Italy.
Insights
Immature platelet fraction (IPF) does not appear to be a reliable indicator for coronary artery disease (CAD) prevalence or severity. Further research is needed to explore potential roles of IPF in cardiovascular health.
Area of Science:
- Cardiology
- Hematology
- Vascular Biology
Background:
- Immature platelet fraction (IPF) represents younger, larger platelets, potentially indicating platelet reactivity.
- IPF is being investigated as a marker for major cardiovascular events.
Purpose of the Study:
- To evaluate the association between IPF levels and the presence and extent of coronary artery disease (CAD).
- To determine if IPF can serve as a biomarker for coronary atherosclerosis in patients undergoing angiography.
Main Methods:
- A cohort of 1789 patients undergoing coronary angiography were analyzed.
- IPF levels were measured using routine blood cell counts.
- Coronary artery disease was defined by vessel stenosis, with severe CAD categorized as left main and/or three-vessel disease.
Main Results:
- IPF levels showed associations with active smoking, non-acute coronary syndrome, higher hemoglobin/uric acid, and lower platelet count.
- No significant differences in angiographic features were observed across IPF quartiles, except for lower TIMI flow and more bifurcation lesions at higher IPF.
- IPF levels did not correlate with the prevalence of CAD or severe left main/three-vessel CAD.
Conclusions:
- The immature platelet fraction (IPF) is not associated with the prevalence or extent of coronary artery disease.
- IPF should not be considered a marker for coronary atherosclerosis in patients undergoing coronary angiography.
Background And Aims:
Immature platelet fraction (IPF) represents the quote of younger and larger sized circulating platelets, a potential marker of platelet reactivity and major cardiovascular events. We aimed to assess the relationship between IPF levels and the prevalence and extent of coronary artery disease (CAD) in patients undergoing coronary angiography.
Methods:
A cohort of consecutive patients undergoing coronary angiography in a single centre were included. Significant CAD was defined as at least 1 vessel stenosis >50%, while severe CAD was defined as left main and/or three-vessel disease. IPF levels were measured at admission by routine blood cells count (A Sysmex XE-2100).
Results:
We included 1789 patients, divided according to quartiles values of IPF. IPF levels were directly related to active smoke (p = 0.02), and non-acute coronary syndrome as indication to angiography (p < 0.001), higher levels of haemoglobin and uric acid (p < 0.001, respectively) and lower platelet count (p = 0.003). Angiographic features did not significantly differ according to quartiles values of IPF, but for a lower degree of TIMI flow in patients with a higher percentage of reticulated platelets (p = 0.01) and a higher rate of lesions involving bifurcations (p = 0.05). IPF levels did not affect the prevalence of CAD (77% vs. 82.2% vs. 79.1% vs. 75.6%, p = 0.34, adjusted OR [95% CI] = 0.93 [0.82-1.05], p = 0.22), nor of severe left main/three-vessel CAD (28.5% vs. 34.4% vs. 32.2% vs. 33.1%, p = 0.27; adjusted OR [95% CI] = 0.99 [0.90-1.1], p = 0.88).
Conclusions:
The present study shows that among patients undergoing coronary angiography, the immature platelet fraction (IPF) is not associated with the prevalence and extent of coronary artery disease, and, therefore, should not be overlooked as a marker of coronary atherosclerosis.