Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oleic acid-derived oleoylethanolamide: A nutritional science perspective.

Kate J Bowen1, Penny M Kris-Etherton1, Gregory C Shearer1

  • 1Department of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Laboratory, University Park, PA 16802, USA.

Progress in Lipid Research
|April 9, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of incorporating 1 avocado per day on lipoprotein particle concentrations compared to habitual intake in adults with abdominal obesity: An ancillary study of the Habitual Diet and Avocado Trial, a randomized controlled trial.

Journal of clinical lipidology·2026
Same author

Gut microbiome drives glycodeoxycholic acid-mediated attenuation of hypertension.

Gut microbes·2026
Same author

The Habitual Diet and Avocado Trial (HAT): A Collaborative Multicenter Model for Large-Scale, Privately Funded Nutrition Research Consortia.

Current developments in nutrition·2026
Same author

Associations of almond, dark chocolate, and cocoa consumption with stool microbial diversity and composition among adults with overweight or obesity: An analysis of secondary outcomes from a 4-period crossover clinical trial.

Clinical nutrition ESPEN·2026
Same author

Leveraging Translational Science to Disseminate Evidence on Using Herbs and Spices to Improve Diet Quality.

Nutrition reviews·2026
Same author

Cardiometabolic and Microbiome Effects of Spices and Herbs.

Nutrition reviews·2026

Oleoylethanolamide (OEA), derived from oleic acid, influences body composition by modulating lipid metabolism and energy intake. This endogenous lipid mediator shows promise for weight management and obesity treatment.

Area of Science:

  • Biochemistry
  • Nutritional Science
  • Endocrinology

Background:

  • Oleoylethanolamide (OEA) is an endogenous lipid mediator synthesized from oleic acid.
  • OEA acts as a high-affinity agonist for the nuclear transcription factor peroxisome proliferator-activated receptor α (PPAR-α).

Purpose of the Study:

  • To explore the role of OEA in mediating the beneficial effects of high-oleic acid diets on body composition.
  • To investigate the mechanisms by which OEA modulates lipid metabolism and energy intake.

Main Methods:

  • Review of clinical studies on high-oleic acid diets and body composition.
  • Analysis of evidence linking OEA to lipid metabolism and appetite regulation.

Main Results:

Keywords:
Body compositionDietary fatLipid metabolismN-acylethanolamineOleic acidOleoylethanolamide

Related Experiment Videos

  • Dietary oleic acid intake increases circulating OEA levels.
  • OEA stimulates fatty acid uptake, lipolysis, and β-oxidation.
  • OEA influences food intake control.

    • Conclusions:

    • OEA may mediate the positive effects of high-oleic acid diets on body composition.
    • OEA presents a potential therapeutic target for weight management and obesity treatment.
    • Further research is needed to confirm these effects and elucidate underlying mechanisms.