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Related Experiment Videos

Tablet compression tooling - Impact of punch face edge modification.

Parthiban Anbalagan1, Paul Wan Sia Heng1, Celine Valeria Liew1

  • 1GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive, 117543, Singapore.

International Journal of Pharmaceutics
|April 9, 2017
PubMed
Summary

Modifying punch face edges to a radius design significantly improves tablet physical quality, tensile strength, and reduces capping. This enhanced tablet compression performance is notable at higher speeds and with extended dwell times.

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Area of Science:

  • Pharmaceutical technology
  • Materials science

Background:

  • Tablet quality is crucial for drug efficacy and patient safety.
  • Punch face edge geometry is a key factor influencing tablet compression.

Purpose of the Study:

  • To investigate the effect of punch face edge geometry modification on tablet compression.
  • To evaluate the physical properties of tablets produced with different punch designs.

Main Methods:

  • Tablets were compressed on a rotary press using punches with modified edge geometries (radius vs. bevel).
  • Physical tablet properties including tensile strength and capping tendency were assessed.
  • Compression parameters like turret speed, precompression force, and dwell time were varied.

Main Results:

Keywords:
CappingPowder compactionPunch faceTablet compression tooling

Related Experiment Videos

  • Radius edge punches produced tablets with superior physical quality, higher tensile strength, and reduced capping.
  • Radius edge geometry facilitated deeper punch penetration, leading to increased compact densification and improved die fill.
  • Enhanced packing efficiency and reduced elastic expansion were observed with radius edge punches, especially at higher turret speeds and longer dwell times.

Conclusions:

  • Modifying punch face edge geometry to a radius design significantly enhances tablet physical quality and compression performance.
  • The radius edge design promotes better densification and reduces capping by improving die fill and managing elastic properties.
  • Optimizing turret speed, precompression, and dwell time further amplifies the benefits of the radius edge punch design.