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Osmolality-regulated arginine vasopressin release in conscious dogs. Evidence for dopaminergic or opioid modulation?
L J Hellebrekers1, E Lagerweij, H W de Vries
1Subdepartment of Veterinary Anesthesia, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
Abstract:
Experiments were performed in conscious dogs, in order to study the possibility of dopaminergic or opioid modulation of the osmolality-regulated release of AVP. Hypertonic saline (20%), infused during a period of 2 h at a rate of 0.03 ml.kg-1.min-1, induced a significant AVP response, which was not influenced by prior administration of bromocriptine or naloxone. Data presented in this report, therefore, are not in support of a dopaminergic or opioid modulation of the osmolality-regulated AVP release in dogs. The results demonstrate a great consistency in individual plasma osmolality-plasma AVP relationships, next to a large inter-individual variation.