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Dynamic aspects in transient hyperphosphatasaemia of infancy
1Department of Paediatrics, Rigshospitalet, University Hospital, Copenhagen, Denmark.
Acta Paediatrica Scandinavica
|May 1, 1988
Summary
Elevated serum alkaline phosphatase (AP) in a child with absence epilepsy normalized after valproic acid treatment. AP elimination followed first-order kinetics with a 6.1-day half-life, coinciding with adenovirus infection.
Area of Science:
- Biochemistry
- Pediatric Neurology
- Pharmacology
Background:
- Absence epilepsy is a common childhood seizure disorder.
- Valproic acid is a widely used antiepileptic drug.
- Elevated serum alkaline phosphatase (AP) can be associated with various medical conditions.
Observation:
- A 20-month-old boy with absence epilepsy presented with markedly high serum AP levels at the initiation of valproic acid therapy.
- Serum AP levels were monitored during valproic acid treatment.
- A concurrent adenovirus infection was identified in the patient.
Findings:
- Serum AP levels demonstrated a decrease over time, consistent with first-order elimination kinetics.
- The calculated half-life for AP elimination was 6.1 days.
- The normalization of AP levels correlated with the discontinuation or reduction of valproic acid therapy, although the concurrent adenovirus infection's role requires further investigation.
Implications:
- This case highlights the potential for valproic acid to influence serum AP levels in pediatric patients.
- Understanding the kinetics of AP elimination aids in managing potential drug-induced biochemical changes.
- Further research is warranted to elucidate the precise relationship between valproic acid, adenovirus infection, and AP levels in children.