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Infection by multiple viruses and lymphocyte abnormalities at the diagnosis of diabetes
H M Surcel1, J Ilonen, M L Käär
1National Public Health Institute, Department of Paediatrics, University of Oulu, Finland.
Acta Paediatrica Scandinavica
|May 1, 1988
Abstract:
Evidence for an ongoing adenovirus infection and preceding EB and Coxsackie B virus infections was found in a 2-year-old boy at the diagnosis of insulin-dependent diabetes. An inverted T-helper/T-suppressor lymphocyte ratio and activation of T cells with a suppressor-cytotoxic phenotype were detected. A combination of multiple viral infections may be responsible for the rapid destruction of pancreatic beta cells in this case.