Serum prolyl hydroxylase protein in experimental liver cancer

Total prolyl hydroxylase protein was measured in serum of rats fed with 0.06% of azodye, 3-methyl-4-dimethyl-aminoazobenzene (3-MeDAB). Serum enzyme protein values in the group progressing to primary hepatoma and those which had the tumors were significantly different (p less than 0.001) from the controls. The results suggest that the assay of serum prolyl hydroxylase protein may be an additional useful tool in the diagnosis of primary hepatic cancer.