Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Concise Review: Stem Cells in Osteoimmunology.

Fernando A Fierro1,2, Jan A Nolta1,2,3, Iannis E Adamopoulos4,5

  • 1Stem Cell Program, University of California at Davis, Sacramento, California, USA.

Stem Cells (Dayton, Ohio)
|April 9, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A humanized engineered heart tissue platform for cardiotoxicity assessment.

Stem cell reports·2026
Same author

Feasibility and safety of cellular therapy for in-utero repair of myelomeningocele (CuRe Trial): a first-in-human, phase 1, single-arm study.

Lancet (London, England)·2026
Same author

Randomized Study of Intravitreal Autologous CD34+ Stem Cells in Central Retinal Vein Occlusion (Treatment of Retinal vein occlusion Using STem cells [TRUST] Report 1): Safety and Feasibility.

Ophthalmology science·2026
Same author

Topical CCL3 Is Well-Tolerated and Improves Liver Function in Diabetic Mice: Evidence from a 14-Day Toxicity Study.

Cells·2026
Same author

Basigin links altered skeletal stem cell lineage dynamics with glucocorticoid-induced bone loss and impaired angiogenesis.

Nature communications·2025
Same author

Osteoimmunology and aging - a frontier to explore.

GeroScience·2025

Bone remodeling involves osteoclasts and osteoblasts. Stem cell modulation during inflammation, particularly involving NFATc1, is crucial for bone formation and resorption, linking inflammation to osteoimmunology.

Area of Science:

  • Stem cell biology
  • Osteoimmunology
  • Bone remodeling

Background:

  • Bone remodeling is a continuous process involving bone resorption by osteoclasts and bone formation by osteoblasts.
  • The differentiation of osteoclasts and osteoblasts from precursors is not fully understood.
  • Recent advances in stem cell biology offer new insights into these differentiation processes.

Purpose of the Study:

  • To review the role of stem cell modulation in bone remodeling during inflammatory conditions.
  • To highlight the connection between inflammation, stem cells, and bone remodeling.
  • To introduce stem cell modulation as a key component of osteoimmunology.

Main Methods:

  • Review of current literature on stem cell biology and bone remodeling.
Keywords:
BoneBone marrowHematopoietic stem cellsMesenchymal stem cellsOsteoblastsOsteoclastsOsteoimmunologySkeletal stem cells

Related Experiment Videos

  • Focus on the role of transcription factor NFATc1.
  • Postulation of stem cell modulation as a prerequisite for bone remodeling in inflammation.

    • Main Results:

    • Inflammatory conditions modulate stem cells, which is essential for bone remodeling.
    • The transcription factor NFATc1 links inflammation to osteoclast and osteoblast differentiation.
    • Stem cell biology advances improve understanding of physiological and pathological differentiation.

    Conclusions:

    • Stem cell modulation during inflammation is a critical factor in bone remodeling.
    • NFATc1 plays a central role in integrating inflammatory signals with bone cell differentiation.
    • This understanding expands the field of osteoimmunology by incorporating stem cell dynamics.