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Vasculitis and Pregnancy.

Leah Machen1, Megan E B Clowse2

  • 1Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Rheumatic Diseases Clinics of North America
|April 10, 2017
PubMed
Summary
This summary is machine-generated.

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Managing vasculitis in women of childbearing age presents unique challenges. Effective disease control before pregnancy, using low-risk medications, can improve pregnancy outcomes and reduce complications like pregnancy loss and preterm birth.

Area of Science:

  • Rheumatology
  • Obstetrics
  • Women's Health

Background:

  • Vasculitis predominantly affects post-menopausal women, making pregnancy management studies rare.
  • Women with vasculitis experience higher rates of pregnancy complications, including pregnancy loss and preterm birth.

Purpose of the Study:

  • To explore the impact of vasculitis on pregnancy outcomes.
  • To identify safe and effective management strategies for pregnant women with vasculitis.

Main Methods:

  • Review of existing literature on vasculitis in pregnancy.
  • Analysis of pregnancy outcomes in relation to disease activity and medication use.

Main Results:

  • Pregnancy complications are elevated in women with vasculitis.
Keywords:
ANCA-associated vasculitisBehçet diseasePrednisonePregnancyTNF-InhibitorTakayasu arteritisVasculitis

Related Experiment Videos

  • Pre-conception disease control may enhance pregnancy success.
  • Certain medications like prednisone, colchicine, azathioprine, and TNF inhibitors are considered low-risk during pregnancy.

    • Conclusions:

    • Effective pre-pregnancy vasculitis management is crucial for improving pregnancy outcomes.
    • Low-risk medications can facilitate desired pregnancies in women with vasculitis.
    • Medications such as cyclophosphamide, methotrexate, and mycophenolate mofetil should be avoided during pregnancy.