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Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes
Ryan P Hobbs1, Susan H Smith2, Spiro Getsios2
1Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
The Journal of Investigative Dermatology
|April 10, 2017
Abstract:
Unchecked inflammation, impaired keratinocyte differentiation, and heightened host defense responses typify psoriasis. Lambert et al. make clever use of psoriasis patient genetics and whole transcriptome RNA-Seq analysis to implicate Act1 in these seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting differentiation and limiting innate immune responses in human keratinocytes.