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Natural product-based amyloid inhibitors.
Paul Velander1, Ling Wu1, Frances Henderson1
1Department of Biochemistry, Virginia Polytechnic Institute & State University, Blacksburg, VA 24061, USA.
Biochemical Pharmacology
|April 10, 2017
Summary
Natural products effectively inhibit toxic protein aggregation linked to chronic diseases like neurodegeneration. This review details their mechanisms and therapeutic potential, including delivery enhancements.
Area of Science:
- Biochemistry
- Pharmacology
- Natural Products Chemistry
Background:
- Chronic human diseases, including neurodegenerative disorders, are often linked to harmful protein aggregates known as amyloids.
- Developing inhibitors to slow, prevent, or remodel toxic amyloids is a key therapeutic strategy.
- Natural products represent a significant source of identified and characterized amyloid inhibitors with demonstrated therapeutic potential.
Purpose of the Study:
- To review recent advancements in natural product-derived amyloid inhibitors.
- To analyze the in vitro mechanisms of action for these inhibitors.
- To explore their molecular interactions with amyloidogenic proteins.
Main Methods:
- Identification and characterization of natural product-based amyloid inhibitors.
- Analysis of molecular and atomic-level interactions (covalent, non-covalent, metal-mediated).
- Review of in vivo animal studies, clinical trials, and nanocarrier delivery systems.
Main Results:
- Numerous natural product classes identified as potent amyloid inhibitors.
- Detailed insights into biochemical and pharmacological mechanisms of inhibition.
- Evidence of therapeutic potential from in vitro and in vivo studies.
Conclusions:
- Natural products offer promising therapeutic strategies for amyloid-related diseases.
- Understanding molecular interactions is crucial for inhibitor design.
- Future research should focus on bioavailability enhancement and clinical translation.