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Neolignans and serratane triterpenoids with inhibitory effects on xanthine oxidase from Palhinhaea cernua
Jing Li1, Ping-Sheng Xu2, Lei-Hong Tan3
1Xiangya Hospital of Central South University, Changsha 410008, PR China; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
Abstract:
Three new neolignans, lycocernuasides B-D (1-3), three new serratane triterpenoids, lycernuic ketones D (8) and E (9), and lycernuic A (10), together with six known compounds, were isolated from the 75% aqueous EtOH extract of Palhinhaea cernua. Their structures and absolute configurations were established primarily by NMR, HRESIMS and circular dichroism (CD). All compounds were evaluated the inhibitory activities of xanthine oxidase. Compounds 1-3 displayed moderate inhibitory effects on xanthine oxidase with IC50 values of 30.36μM, 42.65μM and 35.33μM, respectively.