Decrease of global current source density predicts successful treatment in absence and juvenile myoclonic epilepsies
Johanna Dömötör1, Béla Clemens1, Szilvia Puskás2
1Kenézy Gyula Hospital, Department of Neurology, Bartók Béla út 3., 4031 Debrecen, Hungary.
Objective:
To investigate relationship between treatment efficiency and EEG background activity changes in absence epilepsy (AE) and juvenile myoclonic epilepsy (JME) patients.
Patients And Methods:
EEGs of 31 patients were analysed before treatment and after six months of treatment. Three minutes of artifact-free waking EEG background activity (without epileptiform potentials) were analysed for each patient in both conditions. All the EEG samples were processed to LORETA (Low Resolution Electromagnetic Tomography). Average of all the voxel-wise current source density (CSD) values within the 0.5-8.0Hz frequency range was computed for each EEG. Fischer's exact test was used to investigate association between the global CSD changes and the therapeutic outcome.
Results:
Tight connection was demonstrated between seizure freedom and decreased CSD, and between persisting seizures and increased CSD (p<0.001).
Significance:
An EEG-based biomarker that predicts successful drug treatment was described.
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