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Related Experiment Videos

Improvement of Orbitofrontal Cortex Function Associated with Blephrospasm Symptom Remission.

Chen-Yu Shen1, Yong-Jun Wang, Xiao-Min Liu

  • 1Yuquan Hospital, Clinical Neuroscience Institute, Medical Center, Tsinghua University, Beijing, China.

European Neurology
|April 10, 2017
PubMed
Summary

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Orbitofrontal cortex (OFC) function and cognitive abilities improve as blepharospasm (BSP) symptoms remit. This study shows OFC function is linked to motor and cognitive symptoms in BSP patients.

Area of Science:

  • Neuroscience
  • Cognitive Neurology
  • Medical Imaging

Background:

  • Blepharospasm (BSP) is a focal dystonia characterized by involuntary muscle contractions in the eyelids.
  • Orbitofrontal cortex (OFC) dysfunction has been implicated in various neurological disorders, but its role in BSP, particularly concerning symptom stages, remains unclear.

Purpose of the Study:

  • To investigate whether orbitofrontal cortex (OFC) function, assessed via near-infrared spectroscopy (NIRS), improves with blepharospasm (BSP) symptom remission.
  • To explore the relationship between OFC function, cognitive performance (verbal fluency), and symptom severity in BSP patients.

Main Methods:

  • Nineteen BSP patients and 9 healthy controls (HCs) were recruited.
  • NIRS was used to measure hemoglobin concentration and cerebral blood flow in the OFC during a verbal fluency task.
Keywords:
Blepharospasm onset/remissionNear-infrared spectroscopyPrimary blepharospasm

Related Experiment Videos

  • BSP patients were categorized into onset and remission groups; covariance analysis and post hoc tests were employed to compare OFC function across groups, controlling for age.

    • Main Results:

    • OFC hemoglobin concentration and cerebral blood flow were not significantly different between BSP remission patients and HCs (p > 0.05).
    • Both BSP remission and HC groups showed significantly higher OFC activity compared to the BSP onset group (p < 0.05 for all measured channels).
    • These findings suggest improved OFC function in BSP patients experiencing symptom remission.

    Conclusions:

    • This is the first NIRS study to control for symptom stages in BSP patients.
    • Cognitive abilities and OFC function demonstrate improvement correlating with BSP symptom remission.
    • The OFC appears to be interconnected with both motor and cognitive aspects of BSP, suggesting its potential as a therapeutic target.