Alkalinization of peritoneal dialysis solutions with sodium hydroxide or sodium bicarbonate

Peritoneal dialysis solution containing 1.5% dextrose was titrated with either sodium hydroxide or sodium bicarbonate. The titratable acidity was approximately 1.5 mmol/L as determined by sodium hydroxide titration. Generation of carbon dioxide on addition of sodium bicarbonate resulted in a titration curve that was shifted downward and to the right compared with the curve for sodium hydroxide addition. The information presented can be used to guide the amount of base to be added when partial or complete neutralization of peritoneal dialysis solution is desired.