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Generating pulsatility by pump speed modulation with continuous-flow total artificial heart in awake calves
Kiyotaka Fukamachi1, Jamshid H Karimov2, Gengo Sunagawa3
1Cardiovascular Dynamics Laboratory, Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. fukamak@ccf.org.
Summary
Modulating the speed of the Cleveland Clinic continuous-flow total artificial heart (CFTAH) in calves successfully generated pulsatility. This research demonstrates a method for assessing the hemodynamic effects of artificial heart pulsatility.
Area of Science:
- Biomedical Engineering
- Cardiovascular Physiology
Background:
- Continuous-flow total artificial hearts (CFTAH) lack pulsatility, a natural feature of the native heart.
- Restoring pulsatility may improve device performance and patient outcomes.
Purpose of the Study:
- To evaluate the impact of sinusoidal pump speed modulation in a CFTAH on hemodynamics and pump flow.
- To assess the feasibility of generating pulsatility using CFTAH speed modulation in an awake animal model.
Main Methods:
- Sinusoidal pump speed modulation (±15% and ±25% of mean speed at 80 bpm) was applied to CFTAH devices in four awake calves.
- Hemodynamic parameters including systemic and pulmonary arterial pulse pressures, pulsatility index, and surplus hemodynamic energy were measured.
Main Results:
- Systemic and pulmonary arterial pulse pressures significantly increased with increasing modulation.
- Pulsatility index and surplus hemodynamic energy showed substantial increases at ±15% and ±25% speed modulation.
- Feasible generation of pressure pulsatility was achieved through pump speed modulation.
Conclusions:
- Sinusoidal pump speed modulation is a viable method for introducing pulsatility into CFTAH devices.
- The CFTAH platform facilitates evaluation of pulsatility's physiological impact.
- This approach allows for optimization of speed modulation parameters (magnitude, frequency, profile).