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A new cinnamic acid derivative from plant-derived endophytic fungus Pyronema sp
Zhangshuang Deng1,2, Chengfeng Li1, Dan Luo1
1a Hubei Key Laboratory of Natural Products Research and Development , College of Biological and Pharmaceutical Sciences, China Three Gorges University , Yichang , China.
Abstract:
Ten secondary metabolites (1-10) including a new 4-hydroxycinnamic acid derivatives, methyl 2-{(E)-2-[4-(formyloxy)phenyl]ethenyl}-4-methyl-3-oxopentanoate (1), and nine known compounds (2-10) were isolated from an EtOAc extract derived from a solid rice medium of endophytic fungal strain Pyronema sp. (A2-1 & D1-2). Their structures were elucidated from NMR and HRMS data. All the compounds were tested for antibacterial activity against Mycobacterium marinum ATCCBAA-535. Compounds 1, 8 and 9 exhibited moderate antibiotic activity with IC50 of 64, 43 and 32 μM, respectively.