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Alginate-based microcapsules generated with the coaxial electrospray method for clinical application.

Catherine Barron1, Jia-Qiang He1

  • 1a Department of Biomedical Sciences & Pathobiology , College of Veterinary Medicine, Virginia Polytechnic Institute and State University , Blacksburg , VA , USA.

Journal of Biomaterials Science. Polymer Edition
|April 11, 2017
PubMed
Summary

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Alginate microencapsulation offers immunoisolation for cell transplantation in regenerative medicine. This review explores alginate hydrogels for cell encapsulation, their generation, modifications, and clinical uses in diabetes, heart disease, and neurodegenerative disorders.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Alginate microencapsulation provides crucial immunoisolation for cell transplantation.
  • This technique enables the use of non-autologous cells in clinical trials for severe conditions.

Purpose of the Study:

  • To review alginate hydrogel as an ideal biomaterial for cell encapsulation.
  • To discuss the generation and modification methods of alginate microcapsules.
  • To explore clinical applications in treating diabetes, myocardial infarction, and neurodegenerative diseases.

Main Methods:

  • Alginate hydrogel microencapsulation techniques are well-established for various cell types.
  • The coaxial electrospray method is highlighted for generating uniform microcapsules (~100 μm).
Keywords:
Alginatecell deliveryclinical applicationcoaxial electrospraydiabetesheart infarctionmicroencapsulationneurodegenerative disordersregenerative medicinetissue engineering

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Main Results:

  • Alginate's properties make it suitable for creating microcapsules with tunable diameter, degradation, and composition.
  • The coaxial electrospray method yields homogenous and non-homogenous microcapsules with consistent size.

Conclusions:

  • Alginate-based microencapsulation is a key technology in regenerative medicine and tissue engineering.
  • The review provides insights into optimizing alginate microcapsules for specific clinical treatments and highlights their therapeutic potential.