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Related Experiment Videos

Current smokers with hyperlipidemia lack elevated preβ1-high-density lipoprotein concentrations.

Yuki Nagao1, Satoshi Hirayama1, Mika Kon1

  • 1Department of Clinical Laboratory Medicine, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.

Journal of Clinical Lipidology
|April 11, 2017
PubMed
Summary

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Smoking alters prebeta1-high-density lipoprotein (HDL) metabolism, particularly in individuals with hyperlipidemia. This suggests smoking may negatively impact cardiovascular health by affecting cholesterol transport.

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Atherosclerosis Research

Background:

  • Prebeta1-high-density lipoprotein (HDL) efficiently accepts cell-derived free cholesterol.
  • Lecithin-cholesterol acyltransferase converts free cholesterol into lipid-rich HDL.
  • Elevated prebeta1-HDL is observed in hyperlipidemia, a risk factor for atherosclerosis.

Purpose of the Study:

  • To investigate the impact of smoking on prebeta1-HDL concentrations.
  • To assess alterations in prebeta1-HDL metabolism due to smoking.

Main Methods:

  • Measured prebeta1-HDL concentration and lecithin-cholesterol acyltransferase-dependent conversion rate (CHTpreβ1) in 74 men (39 nonsmokers, 35 smokers) via immunoassay.
  • Grouped participants into normolipidemic and hyperlipidemic categories.
Keywords:
ABCA1Apolipoprotein AICholesterol effluxDyslipidemiaHDL metabolismLCATPrebeta-HDL

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Main Results:

  • Nonsmokers: Hyperlipidemic individuals showed 27% higher prebeta1-HDL than normolipidemic individuals (P < .01).
  • Smokers: No significant difference in prebeta1-HDL between hyperlipidemic and normolipidemic smokers.
  • Correlation: Positive correlation between prebeta1-HDL and CHTpreβ1 in nonsmokers, absent in smokers.

Conclusions:

  • Smoking appears to disadvantage individuals with hyperlipidemia by altering prebeta1-HDL metabolism.
  • Prebeta1-HDL concentrations were lower in hyperlipidemic smokers compared to nonsmokers.
  • CHTpreβ1 was not a significant determinant of prebeta1-HDL in smokers.