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Updated: Oct 20, 2026

09:26
Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
Published on: November 17, 2011
Abstract:
The arachidonic acid substitution by an alternative fatty acid, substrate for the 5-lipoxygenase and the cyclo-oxygenase pathway constitutes a novel therapeutic approach or a complement for other therapeutics in the inflammation area. Eicosapentaenoic acid (EPA), one of the fish oil components, is a substrate for both enzymes and an inhibitor for several enzymes of arachidonic acid cascade, in vitro and in vivo. The EPA-generated metabolites have less pro-inflammatory effects than those produced by arachidonic acid metabolism.

