Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Engineering self-assembled materials to study and direct immune function.

Lisa H Tostanoski1, Christopher M Jewell2

  • 1Fischell Department of Bioengineering, University of Maryland, 8228 Paint Branch Drive, College Park, MD 20742, USA.

Advanced Drug Delivery Reviews
|April 11, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microparticles synthesized from itaconate polyesters enable metabolite delivery and elicit immunoregulatory outcomes.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Integrating molecular dynamics simulations to enable rational assembly of immune signals for immunotherapy.

Nanoscale horizons·2026
Same author

PEGylation strategies for enhanced nanoparticle delivery to tumor-associated immune cells.

Bioengineering & translational medicine·2026
Same author

Optimizing genetic engineering approaches for protein loading into bacterial extracellular vesicles for vaginal drug delivery.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial.

Nature medicine·2026
Same author

BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial.

Nature medicine·2026
Same journal

Silicone oil in protein drug products and its implications for formulation stability.

Advanced drug delivery reviews·2026
Same journal

Targeted delivery of proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD).

Advanced drug delivery reviews·2026
Same journal

Lysosome-targeting degrader delivery system: from formulation design to biomedical applications.

Advanced drug delivery reviews·2026
Same journal

Anti-PEG antibodies in nanomedicine: Mechanisms, risks, and opportunities.

Advanced drug delivery reviews·2026
Same journal

Optimizing macrophage-targeted intracellular delivery systems for safe and effective immunotherapies.

Advanced drug delivery reviews·2026
Same journal

Light-controlled CRISPR-dCas9 epigenome editing: advanced drug-delivery strategies and oncology applications.

Advanced drug delivery reviews·2026
See all related articles
This summary is machine-generated.

Self-assembly offers a novel approach to precisely control immune system signals, enhancing treatments for infections, cancer, and autoimmune diseases by understanding molecular interactions.

Area of Science:

  • Immunology and Materials Science
  • Focuses on the intersection of immune system regulation and self-assembling materials.

Background:

  • The immune system balances pro-immune, regulatory, and homeostatic functions through complex signal integration.
  • Precise control over immune signal delivery is crucial for combating infectious diseases, cancer, and autoimmunity.

Purpose of the Study:

  • To review strategies utilizing self-assembly for precise control of immune system interactions.
  • To explore how self-assembled materials can be used to understand and modulate immune responses.
  • To highlight applications and challenges of self-assembled technologies in medicine.

Main Methods:

  • Review of self-assembly strategies for creating materials with defined compositions and structures.
  • Analysis of how precisely displayed cues from self-assembled materials interact with immune cells and tissues.
Keywords:
Autoimmunity and toleranceBiomaterialCancerImmunomodulationManufacturing, regulatory approval and FDANanoparticle, microparticle, micelle, liposome, polyplex, lipoplex, polyelectrolyte multilayerNanotechnologyNon-covalent, hydrophobic, hydrogen bonding, and electrostatic interactionSelf-assemblySensor, diagnostic, and theranosticVaccine and immunotherapy

Related Experiment Videos

  • Examination of fundamental properties governing immune response magnitude and nature.

    • Main Results:

    • Self-assembly enables the synthesis of materials with controlled molecular arrangements for precise immune signaling.
    • Demonstrated pre-clinical and clinical applications of self-assembled technologies in vaccines, cancer immunotherapy, and autoimmunity treatment.
    • Identified key manufacturing and regulatory challenges for the clinical translation of these technologies.

    Conclusions:

    • Self-assembled materials provide a powerful platform for dissecting and manipulating immune responses.
    • These technologies hold significant promise for developing advanced therapeutics against a range of diseases.
    • Addressing manufacturing and regulatory hurdles is essential for the successful implementation of self-assembled immunotherapies.