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Chitin's Functionality as a Novel Disintegrant: Benchmarking Against Commonly Used Disintegrants in Different
Mohammad Chaheen1, Ian Soulairol2, Bernard Bataille2
1Ecole Doctorale des Sciences et Technologie (EDST), Laboratoire de Valorisation des Ressources Naturelles et Produits de Santé (VRNPS), Université Libanaise, Beirut, Lebanon; Institut Charles Gerhardt, UMR 5253, Equipe MACS, UFR Sciences Pharmaceutiques et Biologiques, Université de Montpellier, Montpellier, France.
Journal of Pharmaceutical Sciences
|April 11, 2017
Summary
Chitin exhibits promising tablet disintegration properties, unaffected by formulation conditions. This natural polymer shows potential as a versatile excipient in pharmaceutical tablet development.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Disintegrants are crucial pharmaceutical excipients ensuring tablet breakdown and drug dissolution.
- Understanding disintegration mechanisms is key to optimizing oral dosage forms.
Purpose of the Study:
- To investigate and compare the disintegration mechanisms of chitin with common pharmaceutical disintegrants.
- To evaluate chitin's functionality as a potential multifunctional excipient.
Main Methods:
- Swelling assessments (force, ratio) in various media.
- Compaction behavior analysis (tabletability, Heckel modeling) of pure and mixed disintegrants.
- Measurement of compact disintegration times.
Main Results:
- Disintegrant functionality is influenced by medium pH, ionic strength, and formulation ingredients.
- Alginic acid calcium salt showed brittle deformation, while crospovidone and chitin exhibited plastic deformation.
- Chitin demonstrated good tabletability and disintegration, independent of the formulation environment.
Conclusions:
- Chitin possesses favorable tabletability and disintegration characteristics.
- Chitin's stability across different formulation environments makes it a promising multifunctional excipient.
- The availability and modifiability of chitin support its use in tablet formulations.