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Paraneoplastic limbic encephalopathy.
1Department of Psychiatry, Cleveland Clinic Foundation, Ohio 44106.
Brain, Behavior, and Immunity
|December 1, 1987
Summary
Paraneoplastic limbic encephalopathy (PLE) is a rare cancer complication causing significant cognitive changes, often preceding cancer diagnosis. This condition primarily affects memory, leading to an amnestic syndrome without widespread intellectual decline.
Area of Science:
- Neurology
- Oncology
Background:
- Paraneoplastic limbic encephalopathy (PLE) is a nonmetastatic complication of carcinoma.
- Neuropsychiatric symptoms can manifest years before cancer diagnosis.
Observation:
- PLE presents with cognitive, affective, and behavioral changes.
- Amnestic syndrome without generalized intellectual decline is a key feature.
- Neuropsychological test results are crucial for diagnosis.
Findings:
- This report details a case of PLE with comprehensive neuropsychological findings.
- A review of similar literature cases highlights common features.
- The study discusses potential causes and clinical implications of PLE.
Implications:
- Early recognition of PLE's neuropsychiatric symptoms is vital for timely cancer detection.
- Understanding PLE's mechanisms can improve patient outcomes.
- This research contributes to the knowledge of autoimmune-mediated neurological disorders in cancer patients.