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Paraneoplastic limbic encephalopathy
1Department of Psychiatry, Cleveland Clinic Foundation, Ohio 44106.
Brain, Behavior, and Immunity
|December 1, 1987
Abstract:
Paraneoplastic limbic encephalopathy (PLE) is a remote, nonmetastatic complication of carcinoma. Neuropsychiatric symptoms consists of cognitive, affective, and behavioral changes that can predate the diagnosis of carcinoma by as much as 6 years. The most striking feature is the development of an amnestic syndrome without generalized intellectual decline. We report a case of PLE, including neuropsychological test results, and review the features of similar cases in the literature. The postulated causes and clinical implications of PLE are discussed.