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Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis
Xiao-Wei Jia1, Ya-Di Yuan1, Zhong-Xiong Yao1
1Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China.
Disease Markers
|April 11, 2017
Summary
Gene variations in Interleukin-4 receptor (IL-4R) are linked to chronic periodontitis, while a specific Interleukin-4 (IL-4) gene variant may reduce aggressive periodontitis risk. This meta-analysis clarifies these associations.
Area of Science:
- Genetics
- Periodontology
- Immunology
Background:
- Periodontitis, a leading cause of tooth loss, is influenced by inflammatory factor gene polymorphisms.
- Previous individual studies yielded inconsistent findings regarding these genetic associations.
Purpose of the Study:
- To conduct a meta-analysis investigating the relationship between periodontitis and Interleukin-4 (IL-4) and Interleukin-4 receptor (IL-4R) gene polymorphisms.
- To clarify the genetic underpinnings of periodontitis susceptibility.
Main Methods:
- Systematic search of case-control studies in multiple databases.
- Independent data extraction and quality assessment by two reviewers.
- Statistical analysis of pooled data from 37 studies (4,385 patients, 5,168 controls).
Main Results:
- No significant association between most IL-4 polymorphisms and periodontitis.
- The IL-4 -33C/T polymorphism (CT genotype) showed a negative association with aggressive periodontitis (AgP) susceptibility.
- The IL-4R Q551R polymorphism was positively associated with chronic periodontitis (CP) susceptibility across three genetic models.
Conclusions:
- The IL-4R Q551R polymorphism is associated with an increased risk of developing chronic periodontitis.
- The IL-4 -33 CT genotype appears to be protective against aggressive periodontitis.
