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Updated: Aug 16, 2026
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Establishing a Competing Risk Regression Nomogram Model for Survival Data
Published on: October 23, 2020
Prognostic factors in gestational trophoblastic tumors. A multivariate analysis
M B Azab1, M H Pejovic, C Theodore
1Department of Medicine, Institut Gustave-Roussy, Villejuif, France.
Cancer
|August 1, 1988
Summary
Gestational trophoblastic tumors (GTT) have a high cure rate (90%). For high-risk patients, nonmolar pregnancy, multiple metastases, and chemotherapy resistance are key indicators of poor prognosis.
Area of Science:
- Oncology
- Gynecologic Oncology
Background:
- Gestational trophoblastic tumors (GTT) are rare but potentially life-threatening gynecologic malignancies.
- Effective chemotherapy regimens have significantly improved outcomes for GTT patients.
Purpose of the Study:
- To identify prognostic factors for complete remission (CR) in patients with GTT.
- To determine predictors of unfavorable outcomes in high-risk GTT patients.
Main Methods:
- Retrospective analysis of 162 GTT cases treated between 1975 and 1985.
- Univariate and multivariate analyses were used to assess prognostic factors.
Main Results:
- An overall CR rate of 90% was achieved.
- Histologic choriocarcinoma was associated with a lower CR rate (75.5%) compared to non-choriocarcinoma GTT.
- Multivariate analysis identified antecedent nonmolar pregnancy, multiple metastatic sites, and primary chemotherapy resistance as significant predictors of poor prognosis in high-risk patients.
Conclusions:
- GTT is highly curable, particularly non-choriocarcinoma types.
- Specific factors like nonmolar pregnancy, extensive metastasis, and treatment resistance are crucial for identifying high-risk GTT patients requiring intensified management.
