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Related Experiment Videos

Reduced future-oriented decision making in individuals with subjective cognitive decline: A functional MRI study.

Xiaochen Hu1, Franziska Uhle2, Klaus Fliessbach3

  • 1Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany; Department of Psychiatry and Psychotherapy, University Hospital of Bonn, Bonn, Germany.

Alzheimer'S & Dementia (Amsterdam, Netherlands)
|April 11, 2017
PubMed
Summary

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Individuals with subjective cognitive decline (SCD) make fewer future-oriented choices. Brain activity differences in controls, but not SCD, during future imagination suggest altered decision-making networks in SCD.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Alzheimer's Disease Research

Background:

  • Subjective cognitive decline (SCD) indicates an elevated risk for Alzheimer's disease.
  • Subtle cognitive deficits are characteristic of SCD, but their impact on complex decision-making is not well understood.

Purpose of the Study:

  • To investigate future-oriented choice behavior in individuals with SCD.
  • To examine the neural correlates of decision-making and future imagination in SCD.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to study intertemporal decision-making in 20 SCD participants and 24 controls.
  • Participants completed tasks involving decisions with and without simultaneous episodic future imagination.

Main Results:

Keywords:
Alzheimer's diseaseDelay discountingEpisodic future imaginationIntertemporal decision makingSubjective cognitive decline

Related Experiment Videos

  • SCD participants exhibited significantly reduced future-oriented choices compared to controls.
  • Future imagination enhanced future-oriented choices in controls, associated with increased activation in medial frontal polar cortex, right insular cortex, and anterior cingulate cortex.
  • In controls, greater future-oriented choices correlated with hippocampal activation during choice processing, an association not observed in the SCD group.

Conclusions:

  • Subtle disruptions in neural networks within the SCD group may explain their tendency towards myopic future decisions.
  • The capacity to modulate choice behavior through episodic future imagination appears impaired in individuals with SCD, suggesting underlying neural network alterations.