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Endocan Levels and Coronary Collateral Circulation in Stable Angina Pectoris: A Pilot Study
Murat Gok1, Harun Kundi1, Emrullah Kiziltunc1
11 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Angiology
|April 11, 2017
Summary
Low endocan levels, a marker of systemic inflammation, are linked to good coronary collateral circulation (CCC) in stable angina patients. Measuring endocan may help predict CCC development in coronary artery disease.
Area of Science:
- Cardiology
- Biomarkers
- Vascular Biology
Background:
- Coronary collateral circulation (CCC) is crucial for myocardial perfusion in coronary artery disease.
- Systemic inflammation plays a role in cardiovascular disease progression.
- Endocan, a novel inflammatory marker, has been implicated in various vascular conditions.
Purpose of the Study:
- To investigate the association between endocan levels and the development of CCC in patients with chronic stable angina pectoris.
- To determine if endocan can serve as a predictor of good CCC.
Main Methods:
- Cross-sectional study including 90 patients with chronic stable angina pectoris.
- Coronary angiography was used to evaluate CCC (categorized as poor or good).
- Endocan and high-sensitivity C-reactive protein (hs-CRP) levels were measured using ELISA.
Main Results:
- Low endocan levels were independently associated with good CCC (P < .001).
- Low hs-CRP levels were also independently associated with good CCC (P = .020).
- An endocan cutoff of 1.7 ng/mL predicted good CCC with 72.4% sensitivity and 65.6% specificity (P < .001).
Conclusions:
- Endocan is a potential independent predictor of good coronary collateral circulation in patients with stable coronary artery disease.
- Measurement of endocan may aid clinicians in assessing CCC development.
- Further research is warranted to explore the therapeutic implications of targeting endocan in CAD.